Background:
@EN The CD34(human progenitor cell antigen) is a monomeric, 115 kD glycoprotein which is expressed on hematopoietic progenitor cells. It is also now known as an immunohistochemical marker of endothelial cell like UEA-I and factor VIII-R Ag and
its
function is thought to be related to endothelial adhesion, migration, and angiogenesis.
@ES Objective:
@EN This study was aimed to investigate the patterns of CD34 expression during the early and late stages of vascular formation in pyogenic granuloma.
@ES Method:
@EN We performed immunoperoxidase staining (ABC technique) by using a monoclonal anti-CD34 antibody (QBEND10, IgG1) on the formalin fixed, paraffin-embedded sections of 19 cases of pyogenic granulomas.
@ES Result:
@EN 1. In all cases of pyogenic granulomas, CD34 was strongly expressed in the endothelial cells of normal vessels in the perilobular stroma and in the endothelial cells of the mature vessels within the lobules of hemangioma.
2. In the foci of immature vessels, most of the endothelial cells located near the small vascular lumina and endothelial cells with intracellular lumen formations expressed CD34. While the endothelial cells far from the vascular lumina and
endothelial
cells without intracellular lumen formations mostly did not express CD34.
@ES Conclusion:
@EN The above results suggested that the expression of CD34 of the endothelial cells vary with the stage of maturation of the vessels. (Kor J Dermatol 1995;33(4) : 693~697)
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